Diffusion Dynamics, Moments, and Distribution of First Passage Time on the Protein-Folding Energy Landscape, with Applications to Single Molecules

We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We obtain information for the first passage-time (FPT) distribution and its moments. The results show a dynamic transition temperature below which the FPT distribution develops a power-law tail, a signature of the intermittency phenomena of the folding dynamics. We also discuss the possible application of the results to single-molecule dynamics experiments

Geo-Social Group Queries with Minimum Acquaintance Constraint

The prosperity of location-based social networking services enables geo-social group queries for group-based activity planning and marketing. This paper proposes a new family of geo-social group queries with minimum acquaintance constraint (GSGQs), which are more appealing than existing geo-social group queries in terms of producing a cohesive group that guarantees the worst-case acquaintance level. GSGQs, also specified with various spatial constraints, are more complex than conventional spatial queries; particularly, those with a strict $k$NN spatial constraint are proved to be NP-hard. For efficient processing of general GSGQ queries on large location-based social networks, we devise two social-aware index structures, namely SaR-tree and SaR*-tree. The latter features a novel clustering technique that considers both spatial and social factors. Based on SaR-tree and SaR*-tree, efficient algorithms are developed to process various GSGQs. Extensive experiments on real-world Gowalla and Dianping datasets show that our proposed methods substantially outperform the baseline algorithms based on R-tree.Comment: This is the preprint version that is accepted by the Very Large Data Bases Journa

A Chinese version of the psychotic symptom rating scales : psychometric properties in recent-onset and chronic psychosis

2016-2017 > Academic research: refereed > Publication in refereed journal201804_a bcmaVersion of RecordPublishe

Maximizing Friend-Making Likelihood for Social Activity Organization

The social presence theory in social psychology suggests that computer-mediated online interactions are inferior to face-to-face, in-person interactions. In this paper, we consider the scenarios of organizing in person friend-making social activities via online social networks (OSNs) and formulate a new research problem, namely, Hop-bounded Maximum Group Friending (HMGF), by modeling both existing friendships and the likelihood of new friend making. To find a set of attendees for socialization activities, HMGF is unique and challenging due to the interplay of the group size, the constraint on existing friendships and the objective function on the likelihood of friend making. We prove that HMGF is NP-Hard, and no approximation algorithm exists unless P = NP. We then propose an error-bounded approximation algorithm to efficiently obtain the solutions very close to the optimal solutions. We conduct a user study to validate our problem formulation and per- form extensive experiments on real datasets to demonstrate the efficiency and effectiveness of our proposed algorithm